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This may, in theory, restore cupro-enzyme function without introducing free ionic copper capable of generating ROS

Topiramate Pharmacology and Mechanism of Action Topiramate has multiple modes of action involving voltage-dependent sodium channels, GABA-receptor subunits, high-voltage calcium channels, and kainate/ -amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) subunits

doi: 10.3389/fpls.2020.600792 Summary Keywords ascorbic acid, fungi, glutathione, reactive oxygen species, water stress Citation Rong Z-Y, Jiang D-J, Cao J-L, Hashem A, Abd_Allah EF, Alsayed MF, Harsonowati W and Wu Q-S (2022) Endophytic fungus Serendipita indica accelerates ascorbate-glutathione cycle of white clover in response to water stress